Programme

Overview: This session delves into the intricate landscape of cancer heterogeneity, where the dynamic interplay of diverse tumour cell states dictate treatment response and toxicity. We will discuss in vitro and in vivo preclinical models used to investigate the molecular effects of radiation. Our expert panel will describe the use of transcriptomics and innovative single-cell techniques to explore therapeutic strategies targeting tumour plasticity, how focal radiation induces distinct intestinal regeneration patterns compared to whole abdomen irradiation, and the role of Notch-signalling in preserving stemness with proton therapy. The presentations aim to bridge the gap between preclinical models and clinical applications, with a focus on enhancing patient care through precision medicine.

Overview: Nodal recurrences are a frequent clinical scenario following local treatment in prostate cancer. The introduction of more sensitive imaging modalities such as PSMA PET-CT have improved visualization of these recurrences. There are no clear guidelines on how to approach these recurrences. From a radiotherapy perspective two different approaches are typically used: a more focal approach with SBRT versus a more elective approach with whole pelvis radiotherapy. In the absence of randomized data, this session will provide you with insights on the pros and cons of both approaches with experts in the field. On Monday the 6th, the first randomized data from the STORM trial will be presented during ESTRO 24.

Overview: This symposium focusses on quality assurance of autosegmentation models and AI-based auto-planning for photon and proton therapy. How robust are they? Are they still adequate after a software update or a change in imaging device? During routine clinical application, do they behave as expected, and how can the clinical benefit be evaluated? What biases are introduced and does this change over time? The importance of estimating uncertainty of autosegmentations is discussed as well as the limitations of the Dice Similarity Coefficient. Finally, the question is considered if the dosimetric impact of contouring variations can be used to minimize manual corrections.

Overview: Daily adaptive radiotherapy (DART) has recently been supported by relevant technological innovations, and we are now approaching the era of daily adaptation of treatment plans based on a patient's evolving anatomy. While manufacturers advocate widespread adoption of DART, some critics argue that this push is driven by commercial interests rather than robust clinical evidence. In addition, the benefits of the DART should also be assessed while maintaining at least the same quality standards. Potential critical issues for discussion include the challenges of technology implementation, regulatory oversight and the need for guidance. This discussion aims to explore the motivations behind manufacturers' promotion of DART and to review the existing clinical evidence to support its widespread adoption

Overview: Mini-Orals are presented at one of the sessions scheduled in the two mini-oral theatres. Each author will present a 4-slide PowerPoint orally for 4 minutes, followed by 3 minutes for discussion. Sessions will not be recorded.

Overview: Mini-Orals are presented at one of the sessions scheduled in the two mini-oral theatres. Each author will present a 4-slide PowerPoint orally for 4 minutes, followed by 3 minutes for discussion. Sessions will not be recorded.

Overview: Poster Discussions are presented in one of the sessions scheduled at the two poster discussion theatres. Each author will present a digital poster orally for 2 minutes, followed by 2 minutes for discussion. Sessions will not be recorded.