Session

Overview: This session will explore the complex role of senescent cells in shaping therapeutic efficacy and long-term consequences. Speakers will provide a comprehensive exploration of radiation-induced senescence across diverse biological contexts. We will examine how radiation-induced senescence in stromal fibroblasts contributes to tumor growth, recurrence, and therapy resistance, driven by the senescence-associated secretory phenotype (SASP). Moreover, the role of radiation-induced senescent cells in the tumor microenvironment of glioblastomas will be presented. Additionally, speakers will delve into the heterogeneity of senescence signatures in normal tissues, with a focus on lung endothelial cells and their role in radiation-induced fibrosis. Finally, we will discuss senescence-driven fibrosis across multiple organ systems and the potential of senolytic therapies to mitigate these effects.