Vienna, Austria

ESTRO 2023

Session

Sunday
May 14
08:45 - 10:00
Lehar 4
Senescence in cancer and stromal cells: Opportunities to improve radiotherapy response
Pelagia Tsoutsou, Switzerland;
Randi Syljuåsen, Norway
Radiation-induced senescent cells may provide a microenvironment that facilitates tumor growth and recurrence. New strategies are currently emerging aimed at improving radiotherapy by eliminating the negative effects of senescent cells. The symposium will cover: 1) intrinsic and extrinsic factors determining senescence-associated phenotypes, 2) senolytic and senomorphic strategies to interfere with therapy-induced senescent cells, 3) senescence and other effects of radiation on cancer-associated fibroblasts (CAFs) derived from lung and head and neck cancers, 4) radiation-induced changes in the immunomodulatory effects of CAFs, and 5) glioblastoma recurrence driven by radiotherapy-induced senescence of tumor and normal brain cells.
2090
Symposium
Radiobiology
08:45 - 09:10
Inigo Martinez-Zubiaurre, Norway
SP-0350
09:10 - 09:35
Sandeep Burma, USA
SP-0352
09:35 - 10:00
Marleen Ansems, The Netherlands
SP-0353