Session

Overview: Preoperative chemoradiation therapy is an integral part of the treatment of advanced rectal cancer. Intensification strategies in the neoadjuvant setting are debated, with improved local control at the cost of increasing toxicity. This session will provide an overview of dose-intensification trials, and what is needed to obtain a complete response. Further, the hype and pitfalls of radiosensitation and concomitant chemotherapy, as well as the total neoadjuvant treatment strategy will be discussed. Updated results from the RAPIDO trial will be presented. Lastly, patient selection to organ preservation strategies will be debated, with prediction models of complete response in the interface between research and clinic.