Single dose HDR brachytherapy is safe for low-risk prostate cancer
SP-0050
Abstract
Single dose HDR brachytherapy is safe for low-risk prostate cancer
1MOUNT VERNON CANCER CENTER, CANCER CENTRE, NORTHWOOD, United Kingdom
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Abstract Text
HDR brachytherapy is a well-established
technique in prostate cancer most commonly used as a single dose boost with
external beam treatment. It has also been explored as sole radiation modality
in schedules delivering a radical dose over 2 to 4 or more fractions. Evidence
from this experience has identified a dose of 36Gy in 4 fractions, 30-32Gy in 3
fractions and 26-27Gy in 2 fractions to all achieve high biochemical relapse
free survival rates with low rates of genitourinary and gastrointestinal
toxicity. Following on from this experience several groups have investigated the
possibility of using a single dose of HDR brachytherapy for localised prostate
cancer. Using a simple linear quadratic model the equivalent dose to the
previous fractionated schedules using an alpha beta value of 1.5 is around
19-20Gy. There are now several cohorts of patients with low risk prostate
cancer treated with monotherapy schedules of 19Gy with several years follow up.
Safety, in terms of both acute and late toxicity is good with low rates of
gastrointestinal and genitourinary toxicity and preserved erectile function.
However there is uncertainty around efficacy with early (2 to 3 years)
biochemical progression free survival rates of 60-94%. A phase II randomised
trial of 19Gy vs 27Gy confirms a lower bPFS after 19Gy with relapses seen
predominantly in the dominant nodule region at presentation. Two questions
emerge from this: (1) is there a subpopulation for whom single dose 19Gy HDR
monotherapy offers safe effective treatment (2) is fractionation essential in
prostate cancer to achieve maximal cell kill or will higher single doses be the
answer.