EMBRACE-II: Image guided intensity modulated external beam radiotherapy and MRI based adaptive brachytherapy in locally advanced cervical cancer1
EMBRACE-I: MRI-guided adaptive brachytherapy in locally advanced cervical cancer: a multicentre prospective cohort study2
Retro-EMBRAVE cohort study on 3D brachytherapy in vaginal cancer3
Retrospective study on 3D brachytherapy in inoperable endometrium cancer4
retroEMBRACE: Retrospective study on image guided brachytherapy in locally advanced cervical cancer5
BIOEMBRACE: Biomarker Expression and Clinical Outcomes in International Study of Chemoradiation and Magnetic Resonance Imaging-Based Image-Guided Brachytherapy for Locally Advanced Cervical Cancer6
IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer7
Management of oligo-metastatic and oligo-recurrent cervical cancer: A pattern of care survey within the EMBRACE research network.8
Recommendations from gynaecological (GYN) GEC-ESTRO working group - ACROP: Target concept for image guided adaptive brachytherapy in primary vaginal cancer. 9
Review on ‘Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer’10
Review on ‘Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer.’ 11
Image registration, contour propagation and dose accumulation of external beam and brachytherapy in gynecological radiotherapy12
Initiatives for education, training, and dissemination of morbidity assessment and reporting in a multiinstitutional international context: Insights from the EMBRACE studies on cervical cancer.13
Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective.14
Late, Persistent, Substantial, Treatment-Related Symptoms After Radiation Therapy (LAPERS): A New Method for Longitudinal Analysis of Late Morbidity-Applied in the EMBRACE Study.15
Vaginal dose point reporting in cervical cancer patients treated with combined 2D/3D external beam radiotherapy and 2D/3D brachytherapy16 and clinical validation in EMBRACE I17
Prediction of isodose surface volumes in cervix cancer brachytherapy from TRAK. A multicenter study.18
Vaginal dose de-escalation in image guided adaptive brachytherapy for locally advanced cervical cancer.19
Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run.20
Multicenter studies on uncertainties of MRI guided brachyterapy in cervix cancer: interobserver variations and intra/interfraction variations21-23
ICRU report 8924
Comparison of DVH parameters and loading patterns of standard loading, manual and inverse optimization for intracavitary brachytherapy on a subset of tandem/ovoid cases.25
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy26
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group: considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy27
Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology.28
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. 29
References
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2. Pötter R, Tanderup K, Schmid MP, et al. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncol. Apr 2021;22(4):538-547. doi:10.1016/s1470-2045(20)30753-1
3. Westerveld H, Schmid MP, Nout RA, et al. Image-Guided Adaptive Brachytherapy (IGABT) for Primary Vaginal Cancer: Results of the International Multicenter RetroEMBRAVE Cohort Study. Cancers (Basel). Mar 23 2021;13(6)doi:10.3390/cancers13061459
4. Rovirosa A, Zhang Y, Chargari C, et al. Exclusive 3D-brachytherapy as a good option for stage-I inoperable endometrial cancer: a retrospective analysis in the gynaecological cancer GEC-ESTRO Working Group. Clin Transl Oncol. Feb 2022;24(2):254-265. doi:10.1007/s12094-021-02680-z
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6. Chopra S, Bosse T, Horeweg N, et al. Biomarker Expression and Clinical Outcomes in International Study of Chemoradiation and Magnetic Resonance Imaging-Based Image-Guided Brachytherapy for Locally Advanced Cervical Cancer: BIOEMBRACE. Int J Radiat Oncol Biol Phys. Jan 1 2025;121(1):97-106. doi:10.1016/j.ijrobp.2024.07.2316
7. Mahantshetty U, Poetter R, Beriwal S, et al. IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer. Radiother Oncol. Jul 2021;160:273-284. doi:10.1016/j.radonc.2021.05.010
8. Chopra S, Mangaj A, Sharma A, et al. Management of oligo-metastatic and oligo-recurrent cervical cancer: A pattern of care survey within the EMBRACE research network. Radiother Oncol. Feb 2021;155:151-159. doi:10.1016/j.radonc.2020.10.037
9. Schmid MP, Fokdal L, Westerveld H, et al. Recommendations from gynaecological (GYN) GEC-ESTRO working group - ACROP: Target concept for image guided adaptive brachytherapy in primary vaginal cancer. Radiother Oncol. Apr 2020;145:36-44. doi:10.1016/j.radonc.2019.11.005
10. Tanderup K, Nesvacil N, Kirchheiner K, et al. Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer. Semin Radiat Oncol. Oct 2020;30(4):311-327. doi:10.1016/j.semradonc.2020.05.008
11. Westerveld H, Nesvacil N, Fokdal L, et al. Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer. Lancet Oncol. Mar 2020;21(3):e157-e167. doi:10.1016/s1470-2045(19)30855-1
12. Swamidas J, Kirisits C, De Brabandere M, Hellebust TP, Siebert FA, Tanderup K. Image registration, contour propagation and dose accumulation of external beam and brachytherapy in gynecological radiotherapy. Radiother Oncol. Feb 2020;143:1-11. doi:10.1016/j.radonc.2019.08.023
13. Kirchheiner K, Smet S, Spampinato S, et al. Initiatives for education, training, and dissemination of morbidity assessment and reporting in a multiinstitutional international context: Insights from the EMBRACE studies on cervical cancer. Brachytherapy. Nov-Dec 2020;19(6):837-849. doi:10.1016/j.brachy.2020.08.011
14. Tan LT, Tanderup K, Kirisits C, et al. Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective. Brachytherapy. Nov-Dec 2020;19(6):827-836. doi:10.1016/j.brachy.2020.06.012
15. Kirchheiner K, Pötter R, Nout RA, et al. Late, Persistent, Substantial, Treatment-Related Symptoms After Radiation Therapy (LAPERS): A New Method for Longitudinal Analysis of Late Morbidity-Applied in the EMBRACE Study. Int J Radiat Oncol Biol Phys. Feb 1 2020;106(2):300-309. doi:10.1016/j.ijrobp.2019.10.027
16. Westerveld H, Pötter R, Berger D, et al. Vaginal dose point reporting in cervical cancer patients treated with combined 2D/3D external beam radiotherapy and 2D/3D brachytherapy. Radiother Oncol. Apr 2013;107(1):99-105. doi:10.1016/j.radonc.2013.04.009
17. Westerveld H, Kirchheiner K, Nout RA, et al. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study. Radiother Oncol. Mar 2022;168:8-15. doi:10.1016/j.radonc.2021.12.034
18. Nkiwane KS, Andersen E, Champoudry J, et al. Total reference air kerma can accurately predict isodose surface volumes in cervix cancer brachytherapy. A multicenter study. Brachytherapy. Nov-Dec 2017;16(6):1184-1191. doi:10.1016/j.brachy.2017.05.011
19. Mohamed S, Lindegaard JC, de Leeuw AA, et al. Vaginal dose de-escalation in image guided adaptive brachytherapy for locally advanced cervical cancer. Radiother Oncol. Sep 2016;120(3):480-485. doi:10.1016/j.radonc.2016.05.020
20. Kirisits C, Federico M, Nkiwane K, et al. Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run. Radiother Oncol. Dec 2015;117(3):548-54. doi:10.1016/j.radonc.2015.08.001
21. Petrič P, Hudej R, Rogelj P, et al. Uncertainties of target volume delineation in MRI guided adaptive brachytherapy of cervix cancer: a multi-institutional study. Radiother Oncol. Apr 2013;107(1):6-12. doi:10.1016/j.radonc.2013.01.014
22. Hellebust TP, Tanderup K, Lervåg C, et al. Dosimetric impact of interobserver variability in MRI-based delineation for cervical cancer brachytherapy. Radiother Oncol. Apr 2013;107(1):13-9. doi:10.1016/j.radonc.2012.12.017
23. Nesvacil N, Tanderup K, Hellebust TP, et al. A multicentre comparison of the dosimetric impact of inter- and intra-fractional anatomical variations in fractionated cervix cancer brachytherapy. Radiother Oncol. Apr 2013;107(1):20-5. doi:10.1016/j.radonc.2013.01.012
24. Report 89. J icru. Apr 2013;13(1-2):Np. doi:10.1093/jicru/ndw042
25. Jamema SV, Kirisits C, Mahantshetty U, et al. Comparison of DVH parameters and loading patterns of standard loading, manual and inverse optimization for intracavitary brachytherapy on a subset of tandem/ovoid cases. Radiother Oncol. Dec 2010;97(3):501-6. doi:10.1016/j.radonc.2010.08.011
26. Dimopoulos JC, Petrow P, Tanderup K, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy. Radiother Oncol. Apr 2012;103(1):113-22. doi:10.1016/j.radonc.2011.12.024
27. Hellebust TP, Kirisits C, Berger D, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group: considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy. Radiother Oncol. Aug 2010;96(2):153-60. doi:10.1016/j.radonc.2010.06.004
28. Pötter R, Haie-Meder C, Van Limbergen E, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. Jan 2006;78(1):67-77. doi:10.1016/j.radonc.2005.11.014
29. Haie-Meder C, Pötter R, Van Limbergen E, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol. Mar 2005;74(3):235-45. doi:10.1016/j.radonc.2004.12.015