Session

Overview: This session delves into the intricate landscape of cancer heterogeneity, where the dynamic interplay of diverse tumour cell states dictate treatment response and toxicity. We will discuss in vitro and in vivo preclinical models used to investigate the molecular effects of radiation. Our expert panel will describe the use of transcriptomics and innovative single-cell techniques to explore therapeutic strategies targeting tumour plasticity, how focal radiation induces distinct intestinal regeneration patterns compared to whole abdomen irradiation, and the role of Notch-signalling in preserving stemness with proton therapy. The presentations aim to bridge the gap between preclinical models and clinical applications, with a focus on enhancing patient care through precision medicine.