Joint DREAM (Dose Response, Experiment, Analysis, Modelling): a physics & radiobiology workshop
Chairs : Heidi Lyng (Norway), Markus Alber (Germany), Mark Jackson (UK), Laure Marignol (Ireland) and Ludwig Dubois (The Netherlands)
Motivation
It is a cliché that radiobiology is where biology and physics meet. It is also a place where cultures clash. This workshop aims to foster communication, awareness and appreciation between the disciplines in the light of the greatest current (and old) challenges and the latest advancements in methodologies and experimental approaches. A broad range of radiobiology could be covered, from the cellular level to clinical data; from dose modification to quantitative clinical endpoints; from microdosimetry to machine learning. The workshop will be in the spirit of bringing problems and solutions together; of seeing the needs of experimentalists, the complexity of the question and the capabilities of the models in one broad picture.
Contributions will be arranged in three topics: expose modellers to the thinking of biologists, expose biologists to the capabilities of new models and data analysis methodologies, and current explorations of dose modifying factors, ranging from radiosensitizers over high-LET radiation to FLASH.
Outcome
Manifesto Appreciation of Models - Awareness of Mutual Needs in Radiobiology
White paper Current most pressing needs for models in radiobiology and radiotherapy
Review AI at the bench: applications of AI for radiobiological experiments
Programme
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Day 1
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9:00–10:00
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ESTRO physics workshop opening keynote lecture
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10:00-10:30
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Coffee break
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10:30-12:30
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Session 1: Defining the Role of Modelling
in Translational Radiobiology
Invited Speaker: TBD
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12:30-13:30
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Lunch
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13:30-15:30
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Session 2: AI for Radiobiology
and Dose Response Modelling
Invited Speaker: Issam el Naqa
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15:30-16:00
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Coffee break
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16:00-17:00
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Progress report of the different topics
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Day 2
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8:00–10:00
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Session 3: Calculation, interpretation & clinical implication of dose
modifying factors
Invited Speaker: Conchita Vens
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10:00-10:30
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Coffee break
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10:30-12:30
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Summary, highlights, discussion on next steps,
identify open issues for further research, outlining the action items
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12:30-13:30
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Lunch
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13:30-14:30
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Discussion of next steps; take home messages;
identify open issues for further research
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14:30-15:30
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Wrap up: highlights and planned next steps
of the different workshops
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15:30-15:45
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Closing remarks
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