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Partial breast irradiation is an attractive option for patients and clinicians as a smaller region of the breast is irradiated in (usually) a shorter time period compared with whole breast radiation therapy (RT). The hypothesis for this approach is that a smaller irradiated volume is likely to translate into decreased toxicity, whilst maintaining good local control and survival (efficacy). This presentation will examine in detail the efficacy and toxicity of the 4 randomised partial breast RT trials using external beam radiotherapy. These include Florence, IMPORT LOW, RAPID and NSABP B-39/RTOG 0413 studies.