Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in head and neck tumours
Zsuzsanna Szilasi,
Hungary
PO-0143
Abstract
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in head and neck tumours
Authors: Zsuzsanna Szilasi1, Valéria Jósa2, Zsombor Zrubka3, Frigyes Helfferich1, Zsolt Baranyai4
1Hungarian Defence Forces Health Centre, ORL-HNS, Budapest, Hungary; 2Jahn Ferenc Hospital, ORL-HNS, Budapest, Hungary; 3Corvinus University , Health Economics, Budapest, Hungary; 4Semmelweis University, Surgery, Budapest, Hungary
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Purpose or Objective
The neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients.
Material and Methods
Clinical data of 156 patients managed for HNSCC at two head and neck surgery centres were analyzed retrospectively. We studied the relationships between survival and PLR as well as NLR.
Results
With regard to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant (p=0.004), and we found the same for disease-free survival (p=0.05), and tumour-specific mortality (p=0.009). Concerning NLR, the difference in tumour-specific survival was statistically significant (p=0.006). According to the multivariate analysis, NLR values higher than the threshold indicated enhanced risk for overall as well as for tumour-specific mortality.
Conclusion
In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival.