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The optimal management of localized Prostate Cancer (PC) should take account consideration of patient and clinical risk factors, as well as patient preferences. The objectives of this cohort study of men with newly diagnosed localized PC were to document side effects with the International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), International Index of Erectile Function Questionnaire (IIEF-5) and as well Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events Questionnaire (PRO-CTCAE) following radiosurgery with the Cyberknife.

In this cohort analysis, 30 patients with localized prostate cancer were analyzed who received Cyberknife radiosurgery (5 x 7 Gy) and completed the IPSS (1-23), ICIQ-SF (0-17), IIEF-5 (6-24) and the German validated PRO-CTCAE questionnaires. 

Mean IPSS score was 6.9 (mild symptomatic), mean ICIQ-SF score was 3.3 (mild impairment of incontinence), mean IIEF-5 score was 17.0 (mild erectile dysfunction). The highest score at PRO-CTCAE was for urinate frequently (one patient, 5%), achieve and maintain erection (one patient, 3,3%), ejaculation problems (two patients, 6,7%) and decreased libido (one patient, 3,3%). There was no significant difference at follow-up period or treated prostate volume (F/U: > 1 vs. < 1 year; Volume ml: >64 vs. < 64). Local control and overall survival were 100%. No patient developed metastasis after radiosurgery. None of our patients died until now.

Robotic Cyberknife radiosurgery for localized prostate cancer shows good local control and overall survival with a very mild side effect profile reported by patients.