Median follow-up was 20 months (range 1-77). 169 (84,5%) patients had a Child-Pugh class A, 28 (14%) a class B, in 3 (1,5%) patients Child-Pugh class was non evaluable. Median lesion size was 25 mm (range 10-120).188 (62,5%) lesions were located in the right liver, 85 (31,2%) in the left liver and 18 (6,2%) in the first segment. 89 (44,5%) lesion were treated with SBRT only while 111 (55,5%) were relapses. During follow-up 167 lesions (57,3%) had a complete response, 57 (19,5%) had a partial response, 35 (12%) were stable and 15 (5,1%) radiological progression. Twenty-eight patients (14%) went to liver transplantation. LC at 12, 24 and 36 months was 99,5%, 98,3% and 98,3% respectively. OS at 12, 24 and 36 months was 79,9%, 63,6% and 53,5% respectively. Till the end of follow-up ninety-two patients (46%) died. CSS at 12, 24 and 36 months was 86,8%,74,1% and 67,6% respectively. PFS at 12, 24 and 36 months was 58,1%, 48,3% and 42,7% respectively. Fifteen patients (7,5%) experienced extra-hepatic failure.15 patients (9%) experienced G3-G4 acute toxicity at the blood chemistry test and 1 patients died for liver failure. Taking into account a Delta-Child score > 2 twelve cases of non-classic Radiation-Induced Liver Disease (RILD) were reported.