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Session Item

RTT track: Risk management/quality management
9350
Poster
RTT
12:20 - 12:30
Prostate Only or Pelvic Radiotherapy in High Risk Prostate Cancer: Outcomes of a Randomised Trial
OC-0613

Abstract

Prostate Only or Pelvic Radiotherapy in High Risk Prostate Cancer: Outcomes of a Randomised Trial
Authors: MURTHY|, VEDANG(1)*[vedangmurthy@gmail.com];MAITRE|, PRIYAMVADA(1);PANIGRAHI|, GITANJALI(1);CHAURASIA|, DIPIKA(1);KRISHNATRY|, RAHUL(1);PHURAILATPAM|, REENA(2);PRAKASH|, GAGAN(3);BAKSHI|, GANESH(3);PAL|, MAHENDRA(3);MENON|, SANTOSH(4);MAHANTSHETTY|, UMESH(1);
(1)ADVANCED CENTRE FOR TREATMENT- RESEARCH AND EDUCATION IN CANCER- MUMBAI, RADIATION ONCOLOGY, MUMBAI, INDIA;(2)ADVANCED CENTRE FOR TREATMENT- RESEARCH AND EDUCATION IN CANCER- MUMBAI, MEDICAL PHYSICS, MUMBAI, INDIA;(3)ADVANCED CENTRE FOR TREATMENT- RESEARCH AND EDUCATION IN CANCER- MUMBAI, UROLOGICAL ONCOLOGY, MUMBAI, INDIA;(4)ADVANCED CENTRE FOR TREATMENT- RESEARCH AND EDUCATION IN CANCER- MUMBAI, PATHOLOGY, MUMBAI, INDIA;
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Purpose or Objective

To report long term clinical outcomes from a randomised trial of prostate only versus whole pelvic radiotherapy in high risk, node negative prostate cancer.

Material and Methods

Patients with node negative, locally advanced prostate adenocarcinoma and Roach nodal risk >20%, were randomised to prostate only (PORT, 68Gy/25# to prostate) or whole pelvis (WPRT, 68Gy/25# to prostate and 50Gy/25# to pelvic nodes as simultaneous integrated boost) arms, with stratification for TURP, Gleason score (GS), baseline PSA, and type of androgen deprivation therapy (ADT). All patients received daily image guided intensity modulated radiotherapy and two years of ADT. Ga[68] PSMA PET-CT was used for disease staging at baseline and recurrence. Primary endpoint was 5-year biochemical failure-free survival (BFFS), defined from the date of randomisation using the Phoenix definition. Survival outcomes were estimated using Kaplan Meier method and compared between the two arms using log rank test.

Conclusion
Released later