I have specific and extensive experience in many areas of medical/clinical physics and radiation biophysics such as modeling and calculation of the relative biological effectiveness of particle radiations (proton and carbon ions), repair kinetics in high-LET radiotherapy and calculation of therapeutic enhancement ratio (TCP/NTCP). I have been involved in mechanistic in vitro and in vivo studies, and have made substantial contributions to areas of new radio biologically optimized proton therapy delivery techniques, such as proton mono-energetic arc therapy