Ludwig Dubois

The Netherlands

Biography

I graduated as Master in the Biomedical Science in 2003 at the Catholic University of Leuven (KUL), Belgium. I obtained my PhD in Medical Sciences from the Department of Radiation Oncology (Maastro Lab) at Maastricht University, The Netherlands, in 2010 with the subject: “Noninvasive imaging of tumor hypoxia, hypoxia response and drug delivery: a bridge towards individualized patient treatment”, under the supervision of Prof. Dr. P. Lambin and Prof. Dr. B.G. Wouters. Following my PhD I worked as team leader of translational imaging and therapy studies in the Department of Radiation Oncology. In 2014 I was appointed Assistant Professor and in 2017 Associate Professor at Maastricht University. I have also completed several postgraduate courses on radiation protection and imaging and am licensed to work with experimental animals (Art. 9 certificate) and with radioactivity (Stralingshygiëne Niv. 5b). In 2013 I obtained the ICH-GCP certificate (renewed in 2017) allowing me to perform clinical research. I (co-)authored >90 peer-reviewed scientific publications (h-index 26 – Web of Sciences, 31 – Google Scholar), 2 patents (WO2011098610 and WO2012087115) and have contributed to scientific meetings (with >110 first/senior author abstracts). I have authored >60 ethically approved animal studies. I am principal or co-investigator on research grants from several national, European, international and company supporting bodies. I have obtained funding from the KWF, the main Dutch funding agency within cancer research, the Worldwide Cancer Research, previously known as AICR as well as from the private sector (Boehringer, Varian). My main areas of interest are directed towards translational research in radiation biology with a focus on small animal functional imaging of hypoxia and therapies directed to hypoxia and its downstream targets. I have a recent interest in preclinical radiation-induced healthy tissue toxicity, the combination of radiation with targeted immunotherapy and preclinical dose painting based on FDG, hypoxia or drug accumulation using a small animal irradiator. I am a member of ESTRO (European Society for Therapeutic Radiology and Oncology), SMI (Society for Molecular Imaging), NVRB (Dutch Society for Radiation Biology) and EACR (European Association for Cancer Research). In the last 5 years I was a participant in the European Union 7th Framework Project - Metoxia (2010–14) and currently from the H2020 Innovative Training Network, Marie Curie actions – Radiate. This, and previous framework projects, have resulted in a thriving network of long-term collaborations with many international partners, leading to many shared peer-reviewed publications. Nationally, I have collaborations with several Dutch universities, while locally, several collaborations to enhance preclinical non-invasive research have been set up. I have an international reputation as an expert in imaging and targeting the tumor microenvironment and am on regular occasions invited speaker for international conferences. For my work in the field of imaging and targeting tumor hypoxia, I was awarded the ESTRO-Varian Juliana Denekamp Award at the 14th International Wolfsberg meeting (2015) on Molecular Radiation Biology/Oncology. I have supervised >30 Masters students and am currently co-promotor of 16 (10 finished) PhD students and am also responsible for the daily supervision of 2 technicians. I teach medical students (block 2.3: “Radiation Oncology” and block 2.6: “Tumor microenvironment - principles and personalized medicine”) and students within the Molecular Life Sciences Bachelor (BMS, block 3.2) and Master program (tUL/MLS, block 1.1 - 1.2 - 1.3 - 2.1 and 2.2) at Maastricht University. In 2015 I obtained my University Teaching Qualification and in 2016 my English level C2 certificate.