Mischa Hoogeman is professor in High-Precision and Adaptive Radiotherapy, head of medical physics of Erasmus MC and HollandPTC and part-time professor at the TU Delft. The overarching aim of his research is to widen the therapeutic window by the development, implementation and evaluation of high-precision radiotherapy techniques. He lead the research group that developed and implemented a novel plan-of-the-day technique to accurately irradiate the highly-deformable target volume of cervical cancer patients. Current research aims to further improve this technique, translate it to Stereotactic Body Radiotherapy, and to clinically evaluate the benefit in terms of reduction in side effects and improved quality of life. With the introduction of proton therapy in the Netherlands the focus of research has shifted to proton therapy. Research in this area includes developing online-adaptive proton therapy by near-real-time daily re-optimization of the treatment plan, quantifying the uncertainties during the delivery of proton therapy that may impair the theoretical benefit, and developing methods to account for those by designing robust treatment plans.